Mitochondrial dysfunction: impact on exercise performance and cellular aging

Innovative noninvasive methods open a new window on the cell in vivo. This window reveals that the tempo of mitochondrial dysfunction with age varies among muscles and in proportion to Type II muscle fiber content. Exercise training can reverse age-related dysfunction, thereby providing an intervent...

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Veröffentlicht in:	Exercise and sport sciences reviews 2007-04, Vol.35 (2), p.43-49
Hauptverfasser:	Conley, Kevin E, Jubrias, Sharon A, Amara, Catherine E, Marcinek, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cellular Senescence - physiology DNA, Mitochondrial Exercise - physiology Humans Mitochondria, Muscle - pathology Mitochondria, Muscle - physiology Muscle, Skeletal - pathology Muscle, Skeletal - physiology Sports Medicine
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Innovative noninvasive methods open a new window on the cell in vivo. This window reveals that the tempo of mitochondrial dysfunction with age varies among muscles and in proportion to Type II muscle fiber content. Exercise training can reverse age-related dysfunction, thereby providing an intervention to slow the pace of aging and disability in the elderly.
ISSN:	0091-6331
DOI:	10.1249/JES.0b013e31803e88e9