Chemotherapy of leishmaniasis Part VI: Synthesis and bioevaluation of some novel terpenyl S, N- and N, N-acetals

Some novel terpene based oxoketene S, N-acetals 2( a– g) and N, N-acetals 3( a– c) have been synthesized from oxoketene dithioacetal 1. The compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50–70% inhibition in the hamster model. [Display omitted] Some novel terpene based oxoketene S, N-acetals 2( a– g) and N, N-acetals 3( a– c) have been synthesized from oxoketene dithioacetal 1 and the compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50–70% inhibition in the hamster model.