Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats
We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500 mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular...
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| Veröffentlicht in: | Journal of ethnopharmacology 2007-05, Vol.111 (2), p.240-247 |
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| creator | Kim, Chan-Sik Sohn, Eun Jin Kim, Young Sook Jung, Dong Ho Jang, Dae Sik Lee, Yun Mi Kim, Dong-Hee Kim, Jin Sook |
| description | We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500
mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that KIOM-79 reduced hyperglycemia (
p
<
0.01), ameliorated insulin resistance (
p
<
0.001), urinary protein excretion (
p
<
0.01) and creatinine clearance (Ccr) (
p
<
0.001), and inhibited glomerular AGE formation (
p
<
0.001) in diabetic GK rats. We also found that KIOM-79 prevented the glomeruli enlargement, overexpression of type IV collagen (
p
<
0.001), PKC protein (
p
<
0.01), TGF-β mRNA (
p
<
0.05) and VEGF mRNA (
p
<
0.05). Thus, based on our finding, KIOM-79 could reduce the hyperglycemia, and prevent or retard the development of diabetic nephropathy. |
| doi_str_mv | 10.1016/j.jep.2006.11.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70362677</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874106006209</els_id><sourcerecordid>70362677</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-bdb25288ffb084cf6fb26243bd623ac5f572e7baf7c27c6724bc6b10a8a2a1f53</originalsourceid><addsrcrecordid>eNp9kcFuEzEQhi0EoqHwAFzAF7jt4vHuejbihKpSqhb1AD1bY6_dOCTrxd4ghafHUSLlxsGag7_5Z_QNY29B1CBAfVrXazfVUghVA9RCNs_YAnqUFXbYPGcL0WBf9djCBXuV81oIgdCKl-wCEJZt16kFM9feOztnHj2_u334XuGSx5Gv9pNLT5u9ddtAnMaBD4GMm4Plo5tWKU40r_Y8jHwuJJfn75s4x-qOfoW_5fFEc37NXnjaZPfmVC_Z49frn1ffqvuHm9urL_eVbRHmygxGdrLvvTeib61X3kgl28YMSjZkO9-hdGjIo5VoFcrWWGVAUE-SwHfNJft4zJ1S_L1zedbbkK3bbGh0cZc1ikZJhVhAOII2xZyT83pKYUtpr0Hog1i91kWsPojVALqILT3vTuE7s3XDueNksgAfTgBlSxufaLQhn7m-TJadKNz7I-cpanpKhXn8IQU05TiIS3VI-nwkXJH1J7iksw1utG4IqZxKDzH8Z9F_yZyeug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70362677</pqid></control><display><type>article</type><title>Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kim, Chan-Sik ; Sohn, Eun Jin ; Kim, Young Sook ; Jung, Dong Ho ; Jang, Dae Sik ; Lee, Yun Mi ; Kim, Dong-Hee ; Kim, Jin Sook</creator><creatorcontrib>Kim, Chan-Sik ; Sohn, Eun Jin ; Kim, Young Sook ; Jung, Dong Ho ; Jang, Dae Sik ; Lee, Yun Mi ; Kim, Dong-Hee ; Kim, Jin Sook</creatorcontrib><description><![CDATA[We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500
mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that KIOM-79 reduced hyperglycemia (
p
<
0.01), ameliorated insulin resistance (
p
<
0.001), urinary protein excretion (
p
<
0.01) and creatinine clearance (Ccr) (
p
<
0.001), and inhibited glomerular AGE formation (
p
<
0.001) in diabetic GK rats. We also found that KIOM-79 prevented the glomeruli enlargement, overexpression of type IV collagen (
p
<
0.001), PKC protein (
p
<
0.01), TGF-β mRNA (
p
<
0.05) and VEGF mRNA (
p
<
0.05). Thus, based on our finding, KIOM-79 could reduce the hyperglycemia, and prevent or retard the development of diabetic nephropathy.]]></description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2006.11.023</identifier><identifier>PMID: 17194556</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Oral ; Animals ; Anti-hyperglycemic effect ; bioassays ; Biological and medical sciences ; Blood Glucose - metabolism ; chemical constituents of plants ; Collagen Type IV - metabolism ; Creatine - analysis ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diabetic Nephropathies - drug therapy ; Diabetic Nephropathies - metabolism ; Diabetic nephropathy ; Drug Administration Schedule ; ethnobotany ; Euphorbia ; Fasting ; General pharmacology ; Glycation End Products, Advanced - metabolism ; Glycyrrhiza ; Goto-Kakizaki rat ; Herbal Medicine ; herbal medicines ; hyperglycemia ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - therapeutic use ; Immunohistochemistry ; Insulin - blood ; Insulin - metabolism ; Insulin Resistance ; Kidney Cortex - drug effects ; Kidney Cortex - metabolism ; kidney diseases ; KIOM-79 ; Magnolia ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; noninsulin-dependent diabetes mellitus ; obesity ; Oriental traditional medicine ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - pharmacology ; Protein Kinase C - metabolism ; Proteinuria - prevention & control ; Pueraria ; Rats ; Rats, Inbred Strains ; RNA, Messenger - metabolism ; roots ; stems ; Transforming Growth Factor beta - metabolism ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Journal of ethnopharmacology, 2007-05, Vol.111 (2), p.240-247</ispartof><rights>2006 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-bdb25288ffb084cf6fb26243bd623ac5f572e7baf7c27c6724bc6b10a8a2a1f53</citedby><cites>FETCH-LOGICAL-c471t-bdb25288ffb084cf6fb26243bd623ac5f572e7baf7c27c6724bc6b10a8a2a1f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2006.11.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18677250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17194556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Chan-Sik</creatorcontrib><creatorcontrib>Sohn, Eun Jin</creatorcontrib><creatorcontrib>Kim, Young Sook</creatorcontrib><creatorcontrib>Jung, Dong Ho</creatorcontrib><creatorcontrib>Jang, Dae Sik</creatorcontrib><creatorcontrib>Lee, Yun Mi</creatorcontrib><creatorcontrib>Kim, Dong-Hee</creatorcontrib><creatorcontrib>Kim, Jin Sook</creatorcontrib><title>Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description><![CDATA[We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500
mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that KIOM-79 reduced hyperglycemia (
p
<
0.01), ameliorated insulin resistance (
p
<
0.001), urinary protein excretion (
p
<
0.01) and creatinine clearance (Ccr) (
p
<
0.001), and inhibited glomerular AGE formation (
p
<
0.001) in diabetic GK rats. We also found that KIOM-79 prevented the glomeruli enlargement, overexpression of type IV collagen (
p
<
0.001), PKC protein (
p
<
0.01), TGF-β mRNA (
p
<
0.05) and VEGF mRNA (
p
<
0.05). Thus, based on our finding, KIOM-79 could reduce the hyperglycemia, and prevent or retard the development of diabetic nephropathy.]]></description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anti-hyperglycemic effect</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>chemical constituents of plants</subject><subject>Collagen Type IV - metabolism</subject><subject>Creatine - analysis</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetic Nephropathies - drug therapy</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic nephropathy</subject><subject>Drug Administration Schedule</subject><subject>ethnobotany</subject><subject>Euphorbia</subject><subject>Fasting</subject><subject>General pharmacology</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glycyrrhiza</subject><subject>Goto-Kakizaki rat</subject><subject>Herbal Medicine</subject><subject>herbal medicines</subject><subject>hyperglycemia</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - isolation & purification</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Immunohistochemistry</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Kidney Cortex - drug effects</subject><subject>Kidney Cortex - metabolism</subject><subject>kidney diseases</subject><subject>KIOM-79</subject><subject>Magnolia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>obesity</subject><subject>Oriental traditional medicine</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Protein Kinase C - metabolism</subject><subject>Proteinuria - prevention & control</subject><subject>Pueraria</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>RNA, Messenger - metabolism</subject><subject>roots</subject><subject>stems</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuEzEQhi0EoqHwAFzAF7jt4vHuejbihKpSqhb1AD1bY6_dOCTrxd4ghafHUSLlxsGag7_5Z_QNY29B1CBAfVrXazfVUghVA9RCNs_YAnqUFXbYPGcL0WBf9djCBXuV81oIgdCKl-wCEJZt16kFM9feOztnHj2_u334XuGSx5Gv9pNLT5u9ddtAnMaBD4GMm4Plo5tWKU40r_Y8jHwuJJfn75s4x-qOfoW_5fFEc37NXnjaZPfmVC_Z49frn1ffqvuHm9urL_eVbRHmygxGdrLvvTeib61X3kgl28YMSjZkO9-hdGjIo5VoFcrWWGVAUE-SwHfNJft4zJ1S_L1zedbbkK3bbGh0cZc1ikZJhVhAOII2xZyT83pKYUtpr0Hog1i91kWsPojVALqILT3vTuE7s3XDueNksgAfTgBlSxufaLQhn7m-TJadKNz7I-cpanpKhXn8IQU05TiIS3VI-nwkXJH1J7iksw1utG4IqZxKDzH8Z9F_yZyeug</recordid><startdate>20070504</startdate><enddate>20070504</enddate><creator>Kim, Chan-Sik</creator><creator>Sohn, Eun Jin</creator><creator>Kim, Young Sook</creator><creator>Jung, Dong Ho</creator><creator>Jang, Dae Sik</creator><creator>Lee, Yun Mi</creator><creator>Kim, Dong-Hee</creator><creator>Kim, Jin Sook</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070504</creationdate><title>Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats</title><author>Kim, Chan-Sik ; Sohn, Eun Jin ; Kim, Young Sook ; Jung, Dong Ho ; Jang, Dae Sik ; Lee, Yun Mi ; Kim, Dong-Hee ; Kim, Jin Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-bdb25288ffb084cf6fb26243bd623ac5f572e7baf7c27c6724bc6b10a8a2a1f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anti-hyperglycemic effect</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>chemical constituents of plants</topic><topic>Collagen Type IV - metabolism</topic><topic>Creatine - analysis</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetic Nephropathies - drug therapy</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Diabetic nephropathy</topic><topic>Drug Administration Schedule</topic><topic>ethnobotany</topic><topic>Euphorbia</topic><topic>Fasting</topic><topic>General pharmacology</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Glycyrrhiza</topic><topic>Goto-Kakizaki rat</topic><topic>Herbal Medicine</topic><topic>herbal medicines</topic><topic>hyperglycemia</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - isolation & purification</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Immunohistochemistry</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Kidney Cortex - drug effects</topic><topic>Kidney Cortex - metabolism</topic><topic>kidney diseases</topic><topic>KIOM-79</topic><topic>Magnolia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>obesity</topic><topic>Oriental traditional medicine</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Protein Kinase C - metabolism</topic><topic>Proteinuria - prevention & control</topic><topic>Pueraria</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>RNA, Messenger - metabolism</topic><topic>roots</topic><topic>stems</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Chan-Sik</creatorcontrib><creatorcontrib>Sohn, Eun Jin</creatorcontrib><creatorcontrib>Kim, Young Sook</creatorcontrib><creatorcontrib>Jung, Dong Ho</creatorcontrib><creatorcontrib>Jang, Dae Sik</creatorcontrib><creatorcontrib>Lee, Yun Mi</creatorcontrib><creatorcontrib>Kim, Dong-Hee</creatorcontrib><creatorcontrib>Kim, Jin Sook</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Chan-Sik</au><au>Sohn, Eun Jin</au><au>Kim, Young Sook</au><au>Jung, Dong Ho</au><au>Jang, Dae Sik</au><au>Lee, Yun Mi</au><au>Kim, Dong-Hee</au><au>Kim, Jin Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2007-05-04</date><risdate>2007</risdate><volume>111</volume><issue>2</issue><spage>240</spage><epage>247</epage><pages>240-247</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract><![CDATA[We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500
mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that KIOM-79 reduced hyperglycemia (
p
<
0.01), ameliorated insulin resistance (
p
<
0.001), urinary protein excretion (
p
<
0.01) and creatinine clearance (Ccr) (
p
<
0.001), and inhibited glomerular AGE formation (
p
<
0.001) in diabetic GK rats. We also found that KIOM-79 prevented the glomeruli enlargement, overexpression of type IV collagen (
p
<
0.001), PKC protein (
p
<
0.01), TGF-β mRNA (
p
<
0.05) and VEGF mRNA (
p
<
0.05). Thus, based on our finding, KIOM-79 could reduce the hyperglycemia, and prevent or retard the development of diabetic nephropathy.]]></abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17194556</pmid><doi>10.1016/j.jep.2006.11.023</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2007-05, Vol.111 (2), p.240-247 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70362677 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Oral Animals Anti-hyperglycemic effect bioassays Biological and medical sciences Blood Glucose - metabolism chemical constituents of plants Collagen Type IV - metabolism Creatine - analysis Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic nephropathy Drug Administration Schedule ethnobotany Euphorbia Fasting General pharmacology Glycation End Products, Advanced - metabolism Glycyrrhiza Goto-Kakizaki rat Herbal Medicine herbal medicines hyperglycemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - therapeutic use Immunohistochemistry Insulin - blood Insulin - metabolism Insulin Resistance Kidney Cortex - drug effects Kidney Cortex - metabolism kidney diseases KIOM-79 Magnolia Male Medical sciences medicinal plants medicinal properties noninsulin-dependent diabetes mellitus obesity Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Protein Kinase C - metabolism Proteinuria - prevention & control Pueraria Rats Rats, Inbred Strains RNA, Messenger - metabolism roots stems Transforming Growth Factor beta - metabolism Vascular Endothelial Growth Factor A - metabolism |
| title | Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats |
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