The 3′ termini of mouse Piwi-interacting RNAs are 2′-O-methylated
Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs teste...
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Veröffentlicht in: | Nature structural & molecular biology 2007-04, Vol.14 (4), p.349-350 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs tested are fully modified by 2′-O-methylation at their 3′ termini. This observation may provide a clue to the biogenesis and function of piRNAs in spermatogenesis. |
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ISSN: | 1545-9993 1545-9985 |
DOI: | 10.1038/nsmb1220 |