The 3′ termini of mouse Piwi-interacting RNAs are 2′-O-methylated

Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs teste...

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Veröffentlicht in:Nature structural & molecular biology 2007-04, Vol.14 (4), p.349-350
Hauptverfasser: Suzuki, Tsutomu, Ohara, Tomoya, Sakaguchi, Yuriko, Suzuki, Takeo, Ueda, Hiroki, Miyauchi, Kenjyo
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Sprache:eng
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Zusammenfassung:Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs tested are fully modified by 2′-O-methylation at their 3′ termini. This observation may provide a clue to the biogenesis and function of piRNAs in spermatogenesis.
ISSN:1545-9993
1545-9985
DOI:10.1038/nsmb1220