Luteinizing Hormone and Follicle-Stimulating Hormone Levels in Extreme Prematurity: Development of Reference Intervals

Establishing pediatric reference intervals has always been challenging, with most ranges used in pediatric laboratories developed over many years. The clinical interpretation of gonadotropins is important in the context of ambiguous genitalia. The aim of this study was to develop reference intervals...

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Veröffentlicht in:	Pediatrics (Evanston) 2008-03, Vol.121 (3), p.e574-e580
Hauptverfasser:	Greaves, Ronda F, Hunt, Rodney W, Chiriano, Angela S, Zacharin, Margaret R
Format:	Artikel
Sprache:	eng
Schlagworte:	Babies Biomarkers - blood Child Development - physiology Cohort Studies Female Fetal Blood - chemistry Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - metabolism Follow-Up Studies Gestational Age Hormones Humans Immunoassay Infant, Extremely Low Birth Weight - blood Infant, Newborn Infant, Premature Luteinizing Hormone - blood Luteinizing Hormone - metabolism Male Pediatrics Predictive Value of Tests Pregnancy Premature birth Reference Values Risk Assessment Sampling Studies Sensitivity and Specificity Studies
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Zusammenfassung:	Establishing pediatric reference intervals has always been challenging, with most ranges used in pediatric laboratories developed over many years. The clinical interpretation of gonadotropins is important in the context of ambiguous genitalia. The aim of this study was to develop reference intervals for luteinizing hormone and follicle-stimulating hormone in infants born between 24 and 29 weeks' gestation. Samples were collected at 0 to 43 days after birth from 82 premature infants born
ISSN:	0031-4005 1098-4275
DOI:	10.1542/peds.2007-1327