Lectins sweet-talk proteins into ERAD

How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a protein is misfolded. The basic strategy of glycan-based recognition, previously identified in yeast, is conserved in mammals but is expanded, poss...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2008-03, Vol.10 (3), p.251-253
Hauptverfasser:	Wang, Songyu, Ng, Davis T. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Research Cell Biology Developmental Biology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Glycosylation Humans Lectins Lectins - metabolism Lectins - physiology Life Sciences Mammals Models, Biological news-and-views Physiological aspects Polysaccharides - chemistry Proteasome Endopeptidase Complex - metabolism Protein Conformation Protein Denaturation Protein Folding Protein Processing, Post-Translational Protein Structure, Tertiary Proteolysis Stem Cells Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a protein is misfolded. The basic strategy of glycan-based recognition, previously identified in yeast, is conserved in mammals but is expanded, possibly to accommodate a more complex client portfolio.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/ncb0308-251