Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines

To cut a long story short. Single‐stranded DNA aptamers that can recognize cancer cells specifically were optimized and modified. The modifications gave rise to aptamers that were much smaller in size (see scheme) and more stable in fetal bovine serum. This stability makes it possible to apply aptam...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2007-04, Vol.8 (6), p.603-606
Hauptverfasser:	Shangguan, Dihua, Tang, Zhiwen, Mallikaratchy, Prabodika, Xiao, Zeyu, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	aptamers Aptamers, Nucleotide - chemistry Cell Line, Tumor - chemistry cell recognition Culture Media - chemistry DNA structures DNA, Single-Stranded - chemistry Evolution, Chemical Humans Leukemia - genetics Leukemia - metabolism Models, Molecular nuclease resistance Nucleic Acid Conformation Oligonucleotides - chemistry Polyethylene Glycols - chemistry
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Beschreibung
Zusammenfassung:	To cut a long story short. Single‐stranded DNA aptamers that can recognize cancer cells specifically were optimized and modified. The modifications gave rise to aptamers that were much smaller in size (see scheme) and more stable in fetal bovine serum. This stability makes it possible to apply aptamers to in vivo applications, such as diagnosis and therapy.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200600532