Glandular function in Sjögren syndrome: assessment with dynamic contrast-enhanced MR imaging and tracer kinetic modeling--initial experience

To prospectively use dynamic contrast material-enhanced magnetic resonance (MR) imaging and a tracer kinetic model to compare parotid gland microvascular characteristics in patients who have Sjögren syndrome (SS) with those in healthy volunteers. The local research ethics committee approved the stud...

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Veröffentlicht in:Radiology 2008-03, Vol.246 (3), p.845-853
Hauptverfasser: Roberts, Caleb, Parker, Geoff J M, Rose, Chris J, Watson, Yvonne, O'Connor, James P, Stivaros, Stavros M, Jackson, Alan, Rushton, Vivian E
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Sprache:eng
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Zusammenfassung:To prospectively use dynamic contrast material-enhanced magnetic resonance (MR) imaging and a tracer kinetic model to compare parotid gland microvascular characteristics in patients who have Sjögren syndrome (SS) with those in healthy volunteers. The local research ethics committee approved the study, and written informed consent was obtained from all participants. Twenty-one patients (19 women, two men; age range, 31-73 years) with a diagnosis of SS and 11 healthy volunteers (10 women, one man; age range, 41-68 years) underwent three-dimensional T1-weighted dynamic contrast-enhanced MR imaging of the parotid gland at 1.5 T. A voxel-wise tracer kinetic model and a model-free analysis were applied to the dynamic MR data. Parameter medians and standard deviations were computed to summarize gland microvascular characteristics and gland heterogeneity, respectively. Differences were investigated by using multivariate analysis of variance, t, or U tests. Further investigation was performed by using linear discriminant and receiver operating characteristic analyses. Compared with the healthy volunteers, the patients with SS had highly significant elevations (P
ISSN:0033-8419
1527-1315
DOI:10.1148/radiol.2463070298