Echinopines A and B:  Sesquiterpenoids Possessing an Unprecedented Skeleton from Echinops spinosus

Echinopines A and B:  Sesquiterpenoids Possessing an Unprecedented Skeleton from Echinops spinosus

Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures were elucidated by extensive spectroscopic analysis. The relative configuration of 1 was assigned by a combination of NOES...

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Veröffentlicht in:Organic letters 2008-03, Vol.10 (5), p.701-704
Hauptverfasser: Dong, Mei, Cong, Bin, Yu, Shu-Hong, Sauriol, Françoise, Huo, Chang-Hong, Shi, Qing-Wen, Gu, Yu-Cheng, Zamir, Lolita O, Kiyota, Hiromasa
Format: Artikel
Sprache:eng
Schlagworte:
Drug Screening Assays, Antitumor
Echinops Plant - chemistry
Female
Humans
Molecular Structure
Plants, Medicinal - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
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Zusammenfassung:Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures were elucidated by extensive spectroscopic analysis. The relative configuration of 1 was assigned by a combination of NOESY correlations and a simulation analysis. A plausible biosynthetic pathway for echinopane was discussed.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol702629z