Copper-Catalyzed Coupling of Hydroxylamines with Aryl Iodides

Copper-Catalyzed Coupling of Hydroxylamines with Aryl Iodides

An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either th...

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Veröffentlicht in:Organic letters 2008-03, Vol.10 (5), p.797-800
Hauptverfasser: Jones, Kerri L, Porzelle, Achim, Hall, Adrian, Woodrow, Michael D, Tomkinson, Nicholas C. O
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Combinatorial Chemistry Techniques
Copper - chemistry
Hydrocarbons, Iodinated - chemistry
Hydroxylamines - chemistry
Molecular Structure
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Zusammenfassung:An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol7029273