SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the Ipr1 gene. Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. We investigated eight SP110 polymorphisms in a Sout...

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Veröffentlicht in:	Human genetics 2007-05, Vol.121 (3-4), p.521-522
Hauptverfasser:	BABB, C, HANEKOM KEET, E, VAN HELDEN, P. D, HOAL, E. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent African Continental Ancestry Group - genetics Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Case-Control Studies Classical genetics, quantitative genetics, hybrids Disease susceptibility Fundamental and applied biological sciences. Psychology Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Haplotypes Human Human bacterial diseases Humans Infectious diseases Investigations Medical sciences Minor Histocompatibility Antigens Nuclear Proteins - genetics Polymorphism Polymorphism, Genetic Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - genetics
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Zusammenfassung:	Susceptibility to tuberculosis (TB) in mice has recently been attributed to the Ipr1 gene. Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. We investigated eight SP110 polymorphisms in a South African population, including two novel polymorphisms. No significant association was found with any of the polymorphisms investigated, including two polymorphisms that were previously found to be associated with TB susceptibility in West African populations.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/s00439-007-0335-1