Prevalence and cost of nonadherence with antiepileptic drugs in an adult managed care population

Summary Purpose: This study assessed the extent of refill nonadherence with antiepileptic drugs (AEDs) and the potential association between AED nonadherence and health care costs in an adult‐managed care population. Methods: Retrospective claims from the PharMetrics database were analyzed. Inclusion criteria were: age ≥21, epilepsy diagnosis between January 01, 2000 and March 12, 2005, ≥2 AED prescriptions, and continuous health plan enrollment for ≥6 months prior to and ≥12 months following AED initiation. Adherence was evaluated using the medication possession ratio (MPR). Patients with an MPR