Cytosine Methylation: Remaining Faithful
DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that i...
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| Veröffentlicht in: | Current biology 2008-02, Vol.18 (4), p.R174-R176 |
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| container_end_page | R176 |
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| container_title | Current biology |
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| creator | Ooi, Steen K.T. Bestor, Timothy H. |
| description | DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that increases the fidelity of maintenance methylation. |
| doi_str_mv | 10.1016/j.cub.2007.12.045 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Current biology, 2008-02, Vol.18 (4), p.R174-R176 |
| issn | 0960-9822 1879-0445 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB Electronic Journals Library |
| subjects | Animals Cytosine - metabolism DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA - metabolism DNA Methylation Genome, Plant Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism |
| title | Cytosine Methylation: Remaining Faithful |
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