Cytosine Methylation: Remaining Faithful

DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that i...

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Veröffentlicht in:	Current biology 2008-02, Vol.18 (4), p.R174-R176
Hauptverfasser:	Ooi, Steen K.T., Bestor, Timothy H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytosine - metabolism DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA - metabolism DNA Methylation Genome, Plant Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that increases the fidelity of maintenance methylation.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2007.12.045