Spectrophotometric simultaneous determination of Rabeprazole Sodium and Itopride Hydrochloride in capsule dosage form

A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the cor...

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Veröffentlicht in:	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2008-03, Vol.69 (3), p.849-852
Hauptverfasser:	Sabnis, Shweta S., Dhavale, Nilesh D., Jadhav, Vijay. Y., Gandhi, Santosh V.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - analysis Benzamides - analysis Benzyl Compounds - analysis Capsules - chemistry Itopride hydrochloride Rabeprazole Rabeprazole sodium Ratio spectra derivative spectrophotometry Reference Standards Solutions Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the corresponding ratio spectra at 231 nm (minima) and 260 nm were selected to determine rabeprazole sodium and itopride hydrochloride, respectively. The method was validated with respect to linearity, precision and accuracy.
ISSN:	1386-1425
DOI:	10.1016/j.saa.2007.05.048