Domino NH/CH Bond Activation: Palladium-Catalyzed Synthesis of Annulated Heterocycles Using Dichloro(hetero)arenes
One after the other: A novel palladium‐catalyzed domino reaction consisting of an amination and a direct CH bond arylation allows for a general synthesis of annulated heterocycles starting from readily available 1,2‐dichloroarenes and primary as well as secondary anilines (see scheme; Cy=cyclohexyl...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2007-01, Vol.46 (10), p.1627-1629 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Ackermann, Lutz Althammer, Andreas |
| description | One after the other: A novel palladium‐catalyzed domino reaction consisting of an amination and a direct CH bond arylation allows for a general synthesis of annulated heterocycles starting from readily available 1,2‐dichloroarenes and primary as well as secondary anilines (see scheme; Cy=cyclohexyl). This is highlighted by an efficient synthesis of the natural product murrayafoline A. |
| doi_str_mv | 10.1002/anie.200603833 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2007-01, Vol.46 (10), p.1627-1629 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alkenes - chemistry Benzene Derivatives - chemistry Catalysis Cyclization CC coupling CH activation domino reactions heterocycles Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Molecular Structure palladium Palladium - chemistry Stereoisomerism |
| title | Domino NH/CH Bond Activation: Palladium-Catalyzed Synthesis of Annulated Heterocycles Using Dichloro(hetero)arenes |
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