Domino NH/CH Bond Activation: Palladium-Catalyzed Synthesis of Annulated Heterocycles Using Dichloro(hetero)arenes

One after the other: A novel palladium‐catalyzed domino reaction consisting of an amination and a direct CH bond arylation allows for a general synthesis of annulated heterocycles starting from readily available 1,2‐dichloroarenes and primary as well as secondary anilines (see scheme; Cy=cyclohexyl...

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Veröffentlicht in:	Angewandte Chemie International Edition 2007-01, Vol.46 (10), p.1627-1629
Hauptverfasser:	Ackermann, Lutz, Althammer, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Benzene Derivatives - chemistry Catalysis Cyclization CC coupling CH activation domino reactions heterocycles Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Molecular Structure palladium Palladium - chemistry Stereoisomerism
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Zusammenfassung:	One after the other: A novel palladium‐catalyzed domino reaction consisting of an amination and a direct CH bond arylation allows for a general synthesis of annulated heterocycles starting from readily available 1,2‐dichloroarenes and primary as well as secondary anilines (see scheme; Cy=cyclohexyl). This is highlighted by an efficient synthesis of the natural product murrayafoline A.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200603833