Stems Cells and the Pathways to Aging and Cancer

Stems Cells and the Pathways to Aging and Cancer

The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell 2008-02, Vol.132 (4), p.681-696
Hauptverfasser: Rossi, Derrick J., Jamieson, Catriona H.M., Weissman, Irving L.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aging - metabolism
Animals
Cellular Senescence
Humans
Neoplasms - metabolism
Signal Transduction
Stem Cells - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the mechanisms underlying stem cell decline and their contribution to disease pathogenesis.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2008.01.036