Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation

Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation Peter B. Sick, Gerhard Schuler, Karl Eugen. Hauptmann, Eberhard Grube, Steve Yakubov, Zoltan G. Turi, Gregory Mishkel, Steve Almany, David R. Holmes In atrial fibrillation (AF)-re...

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Veröffentlicht in:	Journal of the American College of Cardiology 2007-04, Vol.49 (13), p.1490-1495
Hauptverfasser:	Sick, Peter B., MD, Schuler, Gerhard, MD, Hauptmann, Karl Eugen, MD, Grube, Eberhard, MD, FACC, Yakubov, Steve, MD, FACC, Turi, Zoltan G., MD, FACC, Mishkel, Gregory, MD, FACC, Almany, Steve, MD, FACC, Holmes, David R., MD, FACC
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Aspirin Atrial Appendage Atrial Fibrillation - complications Blood clots Cardiac arrhythmia Cardiology Cardiovascular Catheters Diabetes Disease prevention Drug therapy Feasibility Studies Female Follow-Up Studies Global Health Humans Hypertension Internal Medicine Male Medical imaging Middle Aged Molecular weight Pilot Projects Prostheses and Implants Prosthesis Design Risk assessment Stroke Stroke - etiology Stroke - prevention & control
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Zusammenfassung:	Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation Peter B. Sick, Gerhard Schuler, Karl Eugen. Hauptmann, Eberhard Grube, Steve Yakubov, Zoltan G. Turi, Gregory Mishkel, Steve Almany, David R. Holmes In atrial fibrillation (AF)-related strokes, if thrombus formation is present in left atrium, more than 90% are in the appendage. This represents the first worldwide experience with the WATCHMAN Left Atrial Appendage System (Atritech Inc., Plymouth, Minnesota). Major adverse events such as pericardial effusions, air embolism, and device embolizations occurred primarily with a first-generation version of the device and during operator learning curves. Device-related thrombus formation in 4 patients resolved with additional anticoagulation. There were no strokes during follow-up despite discontinuation of anticoagulation. Preliminary data suggest the WATCHMAN System to be a safe and feasible approach to sealing of the LAA in AF.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2007.02.035