Aromatic Polyketides from Marine Algicolous Fungi
The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A (1) and (3R)-7-hydroxy-5-methylmellein (2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromat...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2008-02, Vol.71 (2), p.272-274 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Pontius, Alexander Mohamed, Ietidal Krick, Anja Kehraus, Stefan König, Gabriele M |
| description | The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A (1) and (3R)-7-hydroxy-5-methylmellein (2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins. All structures were elucidated by extensive spectroscopic measurements. |
| doi_str_mv | 10.1021/np0704710 |
| format | Article |
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Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins. All structures were elucidated by extensive spectroscopic measurements.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np0704710</identifier><identifier>PMID: 18197603</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Acremonium ; Acremonium - chemistry ; Ascomycota - chemistry ; Bacillus megaterium - drug effects ; Biological and medical sciences ; Chlorobenzoates - chemistry ; Chlorobenzoates - isolation & purification ; Chlorobenzoates - pharmacology ; Drug Screening Assays, Antitumor ; Escherichia coli - drug effects ; Fundamental and applied biological sciences. Psychology ; Fungi - drug effects ; Isocoumarins - chemistry ; Isocoumarins - isolation & purification ; Isocoumarins - pharmacology ; Marine Biology ; Microbial Sensitivity Tests ; Microbiology ; Molecular Structure ; Morphology, structure, chemical composition ; Mycology ; Nodulisporium</subject><ispartof>Journal of natural products (Washington, D.C.), 2008-02, Vol.71 (2), p.272-274</ispartof><rights>Copyright © 2008 American Chemical Society and American Society of Pharmacognosy and American Society of Pharmacognosy</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a412t-8c1754e756d7e9aeed459857c915a6cbbd5b51ba768fc0619bbefaa738e4548c3</citedby><cites>FETCH-LOGICAL-a412t-8c1754e756d7e9aeed459857c915a6cbbd5b51ba768fc0619bbefaa738e4548c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np0704710$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np0704710$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20148776$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18197603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pontius, Alexander</creatorcontrib><creatorcontrib>Mohamed, Ietidal</creatorcontrib><creatorcontrib>Krick, Anja</creatorcontrib><creatorcontrib>Kehraus, Stefan</creatorcontrib><creatorcontrib>König, Gabriele M</creatorcontrib><title>Aromatic Polyketides from Marine Algicolous Fungi</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A (1) and (3R)-7-hydroxy-5-methylmellein (2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins. All structures were elucidated by extensive spectroscopic measurements.</description><subject>Acremonium</subject><subject>Acremonium - chemistry</subject><subject>Ascomycota - chemistry</subject><subject>Bacillus megaterium - drug effects</subject><subject>Biological and medical sciences</subject><subject>Chlorobenzoates - chemistry</subject><subject>Chlorobenzoates - isolation & purification</subject><subject>Chlorobenzoates - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Escherichia coli - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungi - drug effects</subject><subject>Isocoumarins - chemistry</subject><subject>Isocoumarins - isolation & purification</subject><subject>Isocoumarins - pharmacology</subject><subject>Marine Biology</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Structure</subject><subject>Morphology, structure, chemical composition</subject><subject>Mycology</subject><subject>Nodulisporium</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKxDAUBuAgio6jC19AulFwUT2nuXY5eAdveMFlSNNUop12TFpw3t7KDONGcBVIPv6c8xOyh3CMkOFJMwMJTCKskRHyDFIBGV8nI0BBU6oE2yLbMb4DAIWcb5ItVJhLAXREcBLaqem8TR7aev7hOl-6mFTDZXJrgm9cMqnfvG3rto_JRd-8-R2yUZk6ut3lOSYvF-fPp1fpzf3l9enkJjUMsy5VFiVnTnJRSpcb50rGc8WlzZEbYYui5AXHwkihKgsC86JwlTGSKsc4U5aOyeEidxbaz97FTk99tK6uTeOGYbQEOmxD8V-YgZIZ52KARwtoQxtjcJWeBT81Ya4R9E-RelXkYPeXoX0xdeWvXDY3gIMlMNGaugqmsT6uXAbIlJQ_n6YL52PnvlbvJnxoIank-vnhSb8-3mWXwF712W-usVG_t31ohpL_GPAb7CGUDQ</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Pontius, Alexander</creator><creator>Mohamed, Ietidal</creator><creator>Krick, Anja</creator><creator>Kehraus, Stefan</creator><creator>König, Gabriele M</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Aromatic Polyketides from Marine Algicolous Fungi</title><author>Pontius, Alexander ; Mohamed, Ietidal ; Krick, Anja ; Kehraus, Stefan ; König, Gabriele M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a412t-8c1754e756d7e9aeed459857c915a6cbbd5b51ba768fc0619bbefaa738e4548c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acremonium</topic><topic>Acremonium - chemistry</topic><topic>Ascomycota - chemistry</topic><topic>Bacillus megaterium - drug effects</topic><topic>Biological and medical sciences</topic><topic>Chlorobenzoates - chemistry</topic><topic>Chlorobenzoates - isolation & purification</topic><topic>Chlorobenzoates - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Escherichia coli - drug effects</topic><topic>Fundamental and applied biological sciences. 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Nat. Prod</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>71</volume><issue>2</issue><spage>272</spage><epage>274</epage><pages>272-274</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A (1) and (3R)-7-hydroxy-5-methylmellein (2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins. All structures were elucidated by extensive spectroscopic measurements.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>18197603</pmid><doi>10.1021/np0704710</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2008-02, Vol.71 (2), p.272-274 |
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| source | ACS Publications; MEDLINE |
| subjects | Acremonium Acremonium - chemistry Ascomycota - chemistry Bacillus megaterium - drug effects Biological and medical sciences Chlorobenzoates - chemistry Chlorobenzoates - isolation & purification Chlorobenzoates - pharmacology Drug Screening Assays, Antitumor Escherichia coli - drug effects Fundamental and applied biological sciences. Psychology Fungi - drug effects Isocoumarins - chemistry Isocoumarins - isolation & purification Isocoumarins - pharmacology Marine Biology Microbial Sensitivity Tests Microbiology Molecular Structure Morphology, structure, chemical composition Mycology Nodulisporium |
| title | Aromatic Polyketides from Marine Algicolous Fungi |
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