Aromatic Polyketides from Marine Algicolous Fungi

The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A (1) and (3R)-7-hydroxy-5-methylmellein (2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromat...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-02, Vol.71 (2), p.272-274
Hauptverfasser:	Pontius, Alexander, Mohamed, Ietidal, Krick, Anja, Kehraus, Stefan, König, Gabriele M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acremonium Acremonium - chemistry Ascomycota - chemistry Bacillus megaterium - drug effects Biological and medical sciences Chlorobenzoates - chemistry Chlorobenzoates - isolation & purification Chlorobenzoates - pharmacology Drug Screening Assays, Antitumor Escherichia coli - drug effects Fundamental and applied biological sciences. Psychology Fungi - drug effects Isocoumarins - chemistry Isocoumarins - isolation & purification Isocoumarins - pharmacology Marine Biology Microbial Sensitivity Tests Microbiology Molecular Structure Morphology, structure, chemical composition Mycology Nodulisporium
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Zusammenfassung:	The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A (1) and (3R)-7-hydroxy-5-methylmellein (2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins. All structures were elucidated by extensive spectroscopic measurements.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0704710