Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome

Cardiac allograft vasculopathy is still the main cause of long-term graft loss after heart transplantation. Indeed, recent advances in immunosuppression management led to a significant improvement in short-term survival, while long-term death rate did not change significantly in the last 20 years. I...

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Veröffentlicht in:	Giornale italiano di cardiologia (2006) 2007-02, Vol.8 (2), p.73-82
Hauptverfasser:	Potena, Luciano, Ferrara, Rossella, Mocarski, Edward S, Lewis, David B, Cooke, John P, Grigioni, Francesco, Coccolo, Fabio, Magnani, Gaia, Fallani, Francesco, Magelli, Carlo, Valantine, Hannah A, Branzi, Angelo
Format:	Artikel
Sprache:	ita
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - metabolism Clinical Trials as Topic Coronary Disease - etiology Coronary Disease - immunology Coronary Disease - metabolism Coronary Disease - mortality Coronary Disease - prevention & control Coronary Disease - therapy Cytomegalovirus Infections - complications Cytomegalovirus Infections - prevention & control Disease Models, Animal Endothelium, Vascular - physiology Graft Rejection Graft Survival Heart Transplantation - adverse effects Heart Transplantation - mortality Humans Hypolipidemic Agents - therapeutic use Immunosuppression Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Metabolic Syndrome - complications Quality of Life Risk Assessment Risk Factors Rodentia Stents Time Factors
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Zusammenfassung:	Cardiac allograft vasculopathy is still the main cause of long-term graft loss after heart transplantation. Indeed, recent advances in immunosuppression management led to a significant improvement in short-term survival, while long-term death rate did not change significantly in the last 20 years. In this paper, we will review the latest advances in the understanding of this peculiar form of atherosclerosis, focusing on the mechanisms that can be potentially targeted by specific therapeutic interventions.
ISSN:	1827-6806