Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum

Polyketides, leptosphaerone C ( 1), penicillenone ( 2), arugosin I ( 3) and 9-demethyl FR-901235 ( 4), were produced by the endophytic fungus Penicillium sp. Compounds 1 and 2 showed cytotoxicity against A-549 and P388 cells, respectively. Four polyketides, leptosphaerone C ( 1), penicillenone ( 2),...

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Veröffentlicht in:	Phytochemistry (Oxford) 2008-03, Vol.69 (5), p.1273-1278
Hauptverfasser:	Lin, Zhenjian, Zhu, Tianjiao, Fang, Yuchun, Gu, Qianqun, Zhu, Weiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aegiceras corniculatum Animals anticarcinogenic activity arugosin Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Chemical constitution chemical structure cultured cells Cyclohexanones - chemistry Cyclohexanones - isolation & purification Cyclohexanones - pharmacology Cytotoxicity Drug Screening Assays, Antitumor endophytes Endophytic fungi Fundamental and applied biological sciences. Psychology Humans leptosphaerone Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Magnetic Resonance Spectroscopy - methods Magnetic Resonance Spectroscopy - standards medicinal properties Metabolism Metabolism. Physicochemical requirements Mice Molecular Conformation Myrsinaceae Myrsinaceae - microbiology penicillenone Penicillium Penicillium - chemistry Penicillium - isolation & purification Phenalenes - chemistry Phenalenes - isolation & purification Phenalenes - pharmacology Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant physiology and development Polyketides Reference Standards spectral analysis Stereoisomerism Structure-Activity Relationship
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