Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction

Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction

Asymmetric desymmetrization of 4-substituted cyclohexanones using proline amide-catalyzed direct aldol reaction afforded beta-hydroxyketones with three stereogenic centers in high enantioselectivities of up to >99% ee.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2007-01 (7), p.736-738
Hauptverfasser: Jiang, Jun, He, Long, Luo, Shi-Wei, Cun, Lin-Feng, Gong, Liu-Zhu
Format: Artikel
Sprache:eng
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Zusammenfassung:Asymmetric desymmetrization of 4-substituted cyclohexanones using proline amide-catalyzed direct aldol reaction afforded beta-hydroxyketones with three stereogenic centers in high enantioselectivities of up to >99% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/b615043h