Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure

Abstract Aim Endothelial activation and dysfunction may be an important contributor to chronic heart failure (CHF) progression. We sought to investigate whether the calcium sensitizer levosimendan affects beneficially endothelial function and attenuates the deleterious effects of soluble adhesion mo...

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Veröffentlicht in:	Atherosclerosis 2008-03, Vol.197 (1), p.278-282
Hauptverfasser:	Parissis, John T, Karavidas, Apostolos, Bistola, Vassiliki, Arapi, Sophia, Paraskevaidis, Ioannis A, Farmakis, Dimitrios, Korres, Dimitrios, Filippatos, Gerasimos, Matsakas, Evaggelos, Kremastinos, Dimitrios T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecules Advanced heart failure Aged Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular system Chronic Disease Endothelial dysfunction Endothelium, Vascular - drug effects Female Flow-mediated vasodilation Heart Failure - drug therapy Heart Failure - metabolism Heart Failure - physiopathology Humans Hydrazones - administration & dosage Intercellular Adhesion Molecule-1 - blood Interleukin-6 - blood Levosimendan Male Medical sciences Middle Aged Natriuretic Peptide, Brain - blood Nitroglycerin - administration & dosage Pharmacology. Drug treatments Pyridazines - administration & dosage Severity of Illness Index Solubility Stroke Volume Vascular Cell Adhesion Molecule-1 - blood Vasodilation - drug effects Vasodilator Agents - administration & dosage Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	Abstract Aim Endothelial activation and dysfunction may be an important contributor to chronic heart failure (CHF) progression. We sought to investigate whether the calcium sensitizer levosimendan affects beneficially endothelial function and attenuates the deleterious effects of soluble adhesion molecules in patients with advanced CHF. Methods Twenty-six advanced CHF patients (mean New York Heart Association class, 2.6 ± 0.3; ischemic/dilated, 18/8; mean left ventricular ejection fraction
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2007.04.023