Expression of RBM5-related factors in primary breast tissue

The aim of this study was to examine the expression of the RBM5 tumor suppressor, in relation to RBM6 and RBM10, to obtain a better understanding of the potential role played by these RBM5‐related factors in the regulation of RBM5 tumor‐suppressor activity. Paired non‐tumor and tumor samples were obtained from 73 breast cancer patients. RNA and protein expression were examined by semi‐quantitative reverse transcription‐polymerase chain reaction and immunoblot, respectively. Data were analyzed using various statistical methods to test for correlations amongst the RBM5‐related factors, and between the factors and various pathological parameters. Most notably, RBM5, RBM10v1, and HER2 protein expression levels were elevated in tumor tissue (P