Low-dose oral tri-iodothyronine does not directly increase food intake in man

Low-dose oral tri-iodothyronine does not directly increase food intake in man

Previously, we have shown that low-dose tri-iodothyronine (T3) increases food intake in rodents. This randomised, double-blind, placebo-controlled study aimed to investigate the effects of low-dose T3 on food intake in normal body weight individuals. However, despite an elevation in fT3 comparable t...

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Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2007-05, Vol.9 (3), p.435-437
Hauptverfasser: Martin, N.M, Small, C.J, Lee, J.L, Ellis, S, Dhillo, W.S, Smith, K.L, Kong, W.M, Frost, G.S, Bloom, S.R
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
appetite
Cross-Over Studies
Double-Blind Method
Eating - drug effects
Eating - physiology
energy expenditure
Energy Intake - physiology
Energy Metabolism - physiology
food intake
Humans
Male
Thyrotropin - blood
thyroxine
tri-iodothyronine
Triiodothyronine - administration & dosage
Triiodothyronine - blood
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Zusammenfassung:Previously, we have shown that low-dose tri-iodothyronine (T3) increases food intake in rodents. This randomised, double-blind, placebo-controlled study aimed to investigate the effects of low-dose T3 on food intake in normal body weight individuals. However, despite an elevation in fT3 comparable to our earlier studies, administration of low-dose T3 in the fasted state did not stimulate food intake in man.
ISSN:1463-1326
1462-8902
1463-1326
DOI:10.1111/j.1463-1326.2006.00613.x