An antioxidant effect by acyclic retinoid suppresses liver tumor in mice
The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor wer...
Gespeichert in:
| Veröffentlicht in: | Biochemical pharmacology 2007-05, Vol.73 (9), p.1405-1411 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1411 |
|---|---|
| container_issue | 9 |
| container_start_page | 1405 |
| container_title | Biochemical pharmacology |
| container_volume | 73 |
| creator | Sakabe, Tomohiko Tsuchiya, Hiroyuki Endo, Michiko Tomita, Akiko Ishii, Kyoko Gonda, Kazue Murai, Rie Takubo, Kazuko Hoshikawa, Yoshiko Kurimasa, Akihiro Ishibashi, Naoto Yanagida, Shingo Shiota, Goshi |
| description | The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor were used. The effect of NIK-333 on hepatocarcinogenesis in RARE mice was studied. The RARE mice were examined after feeding 0.03% and 0.06% NIK-333 diets at 12 months of age. In the mice fed 0.06% NIK-333 diet, tumor incidence was greatly suppressed, compared to that of wild type mice (0/9 versus 5/9, P |
| doi_str_mv | 10.1016/j.bcp.2006.12.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70316137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006295207000020</els_id><sourcerecordid>70316137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-3cc0480c19256eca8844609cceb58c6691a7d9138b42c313af329dc281dd48993</originalsourceid><addsrcrecordid>eNp9kE1rGzEQhkVpadykP6CXoEtz81YjrbVaejImqQuBXpqz0I5mQWa_Iu2G-t9HxgbfepoZ5nmH4WHsG4gCBOgfh6LBqZBC6AJkIZT4wFZgKrWWtTYf2UrkTe438oZ9SelwGo2Gz-wGKqlBVmrF9tuBu2EO47_gc-XUtoQzb47c4RG7gDzSHIYxeJ6WaYqUEiXehTeKfF76MfIw8D4g3bFPresSfb3UW_by9Ph3t18___n1e7d9XmNZVvNaIYrSCIRabjShM6YstagRqdkY1LoGV_kalGlKiQqUa5WsPUoD3pemrtUtezjfneL4ulCabR8SUte5gcYl2Uoo0KCqDMIZxDimFKm1Uwy9i0cLwp702YPN-uxJnwVps76cub8cX5qe_DVx8ZWB7xfAJXRdG92AIV05o0u5kZC5n2eOsoq3QNEmDDQg-RCzX-vH8J833gGiFYw0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70316137</pqid></control><display><type>article</type><title>An antioxidant effect by acyclic retinoid suppresses liver tumor in mice</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Sakabe, Tomohiko ; Tsuchiya, Hiroyuki ; Endo, Michiko ; Tomita, Akiko ; Ishii, Kyoko ; Gonda, Kazue ; Murai, Rie ; Takubo, Kazuko ; Hoshikawa, Yoshiko ; Kurimasa, Akihiro ; Ishibashi, Naoto ; Yanagida, Shingo ; Shiota, Goshi</creator><creatorcontrib>Sakabe, Tomohiko ; Tsuchiya, Hiroyuki ; Endo, Michiko ; Tomita, Akiko ; Ishii, Kyoko ; Gonda, Kazue ; Murai, Rie ; Takubo, Kazuko ; Hoshikawa, Yoshiko ; Kurimasa, Akihiro ; Ishibashi, Naoto ; Yanagida, Shingo ; Shiota, Goshi</creatorcontrib><description>The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor were used. The effect of NIK-333 on hepatocarcinogenesis in RARE mice was studied. The RARE mice were examined after feeding 0.03% and 0.06% NIK-333 diets at 12 months of age. In the mice fed 0.06% NIK-333 diet, tumor incidence was greatly suppressed, compared to that of wild type mice (0/9 versus 5/9, P<0.05), but not in the mice fed 0.03% NIK-333 diet. In addition, expression of cytochrome p450 4a14 and acyl-CoA oxidase was normalized, and the percentages of positive cells for 8-hydroxy-2′-deoxyguanosine, 4-hydroxy-2-nonenal and proliferating cell nuclear antigen were decreased. Furthermore, expression of β-catenin and cyclin D1 was also depressed. These data suggest that NIK-333 suppressed liver tumor in association with repression of oxidative stress.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/j.bcp.2006.12.030</identifier><identifier>PMID: 17261273</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acyclic retinoid ; Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Antioxidative effect ; Biological and medical sciences ; Chemoprevention ; Disease Models, Animal ; Lipid metabolism ; Liver Neoplasms - prevention & control ; Liver tumor ; Medical sciences ; Mice ; Mice, Transgenic ; Neoplasm Transplantation ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Pharmacology. Drug treatments ; Tretinoin - analogs & derivatives ; Tretinoin - pharmacology ; Tretinoin - therapeutic use ; Xenograft Model Antitumor Assays</subject><ispartof>Biochemical pharmacology, 2007-05, Vol.73 (9), p.1405-1411</ispartof><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-3cc0480c19256eca8844609cceb58c6691a7d9138b42c313af329dc281dd48993</citedby><cites>FETCH-LOGICAL-c447t-3cc0480c19256eca8844609cceb58c6691a7d9138b42c313af329dc281dd48993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bcp.2006.12.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18642521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17261273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakabe, Tomohiko</creatorcontrib><creatorcontrib>Tsuchiya, Hiroyuki</creatorcontrib><creatorcontrib>Endo, Michiko</creatorcontrib><creatorcontrib>Tomita, Akiko</creatorcontrib><creatorcontrib>Ishii, Kyoko</creatorcontrib><creatorcontrib>Gonda, Kazue</creatorcontrib><creatorcontrib>Murai, Rie</creatorcontrib><creatorcontrib>Takubo, Kazuko</creatorcontrib><creatorcontrib>Hoshikawa, Yoshiko</creatorcontrib><creatorcontrib>Kurimasa, Akihiro</creatorcontrib><creatorcontrib>Ishibashi, Naoto</creatorcontrib><creatorcontrib>Yanagida, Shingo</creatorcontrib><creatorcontrib>Shiota, Goshi</creatorcontrib><title>An antioxidant effect by acyclic retinoid suppresses liver tumor in mice</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor were used. The effect of NIK-333 on hepatocarcinogenesis in RARE mice was studied. The RARE mice were examined after feeding 0.03% and 0.06% NIK-333 diets at 12 months of age. In the mice fed 0.06% NIK-333 diet, tumor incidence was greatly suppressed, compared to that of wild type mice (0/9 versus 5/9, P<0.05), but not in the mice fed 0.03% NIK-333 diet. In addition, expression of cytochrome p450 4a14 and acyl-CoA oxidase was normalized, and the percentages of positive cells for 8-hydroxy-2′-deoxyguanosine, 4-hydroxy-2-nonenal and proliferating cell nuclear antigen were decreased. Furthermore, expression of β-catenin and cyclin D1 was also depressed. These data suggest that NIK-333 suppressed liver tumor in association with repression of oxidative stress.</description><subject>Acyclic retinoid</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Antioxidative effect</subject><subject>Biological and medical sciences</subject><subject>Chemoprevention</subject><subject>Disease Models, Animal</subject><subject>Lipid metabolism</subject><subject>Liver Neoplasms - prevention & control</subject><subject>Liver tumor</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Neoplasm Transplantation</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Tretinoin - analogs & derivatives</subject><subject>Tretinoin - pharmacology</subject><subject>Tretinoin - therapeutic use</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVpadykP6CXoEtz81YjrbVaejImqQuBXpqz0I5mQWa_Iu2G-t9HxgbfepoZ5nmH4WHsG4gCBOgfh6LBqZBC6AJkIZT4wFZgKrWWtTYf2UrkTe438oZ9SelwGo2Gz-wGKqlBVmrF9tuBu2EO47_gc-XUtoQzb47c4RG7gDzSHIYxeJ6WaYqUEiXehTeKfF76MfIw8D4g3bFPresSfb3UW_by9Ph3t18___n1e7d9XmNZVvNaIYrSCIRabjShM6YstagRqdkY1LoGV_kalGlKiQqUa5WsPUoD3pemrtUtezjfneL4ulCabR8SUte5gcYl2Uoo0KCqDMIZxDimFKm1Uwy9i0cLwp702YPN-uxJnwVps76cub8cX5qe_DVx8ZWB7xfAJXRdG92AIV05o0u5kZC5n2eOsoq3QNEmDDQg-RCzX-vH8J833gGiFYw0</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Sakabe, Tomohiko</creator><creator>Tsuchiya, Hiroyuki</creator><creator>Endo, Michiko</creator><creator>Tomita, Akiko</creator><creator>Ishii, Kyoko</creator><creator>Gonda, Kazue</creator><creator>Murai, Rie</creator><creator>Takubo, Kazuko</creator><creator>Hoshikawa, Yoshiko</creator><creator>Kurimasa, Akihiro</creator><creator>Ishibashi, Naoto</creator><creator>Yanagida, Shingo</creator><creator>Shiota, Goshi</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>An antioxidant effect by acyclic retinoid suppresses liver tumor in mice</title><author>Sakabe, Tomohiko ; Tsuchiya, Hiroyuki ; Endo, Michiko ; Tomita, Akiko ; Ishii, Kyoko ; Gonda, Kazue ; Murai, Rie ; Takubo, Kazuko ; Hoshikawa, Yoshiko ; Kurimasa, Akihiro ; Ishibashi, Naoto ; Yanagida, Shingo ; Shiota, Goshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-3cc0480c19256eca8844609cceb58c6691a7d9138b42c313af329dc281dd48993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acyclic retinoid</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Antioxidative effect</topic><topic>Biological and medical sciences</topic><topic>Chemoprevention</topic><topic>Disease Models, Animal</topic><topic>Lipid metabolism</topic><topic>Liver Neoplasms - prevention & control</topic><topic>Liver tumor</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Neoplasm Transplantation</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Tretinoin - analogs & derivatives</topic><topic>Tretinoin - pharmacology</topic><topic>Tretinoin - therapeutic use</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakabe, Tomohiko</creatorcontrib><creatorcontrib>Tsuchiya, Hiroyuki</creatorcontrib><creatorcontrib>Endo, Michiko</creatorcontrib><creatorcontrib>Tomita, Akiko</creatorcontrib><creatorcontrib>Ishii, Kyoko</creatorcontrib><creatorcontrib>Gonda, Kazue</creatorcontrib><creatorcontrib>Murai, Rie</creatorcontrib><creatorcontrib>Takubo, Kazuko</creatorcontrib><creatorcontrib>Hoshikawa, Yoshiko</creatorcontrib><creatorcontrib>Kurimasa, Akihiro</creatorcontrib><creatorcontrib>Ishibashi, Naoto</creatorcontrib><creatorcontrib>Yanagida, Shingo</creatorcontrib><creatorcontrib>Shiota, Goshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakabe, Tomohiko</au><au>Tsuchiya, Hiroyuki</au><au>Endo, Michiko</au><au>Tomita, Akiko</au><au>Ishii, Kyoko</au><au>Gonda, Kazue</au><au>Murai, Rie</au><au>Takubo, Kazuko</au><au>Hoshikawa, Yoshiko</au><au>Kurimasa, Akihiro</au><au>Ishibashi, Naoto</au><au>Yanagida, Shingo</au><au>Shiota, Goshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An antioxidant effect by acyclic retinoid suppresses liver tumor in mice</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>73</volume><issue>9</issue><spage>1405</spage><epage>1411</epage><pages>1405-1411</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor were used. The effect of NIK-333 on hepatocarcinogenesis in RARE mice was studied. The RARE mice were examined after feeding 0.03% and 0.06% NIK-333 diets at 12 months of age. In the mice fed 0.06% NIK-333 diet, tumor incidence was greatly suppressed, compared to that of wild type mice (0/9 versus 5/9, P<0.05), but not in the mice fed 0.03% NIK-333 diet. In addition, expression of cytochrome p450 4a14 and acyl-CoA oxidase was normalized, and the percentages of positive cells for 8-hydroxy-2′-deoxyguanosine, 4-hydroxy-2-nonenal and proliferating cell nuclear antigen were decreased. Furthermore, expression of β-catenin and cyclin D1 was also depressed. These data suggest that NIK-333 suppressed liver tumor in association with repression of oxidative stress.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17261273</pmid><doi>10.1016/j.bcp.2006.12.030</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 2007-05, Vol.73 (9), p.1405-1411 |
| issn | 0006-2952 1873-2968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70316137 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acyclic retinoid Animals Antioxidants - pharmacology Antioxidants - therapeutic use Antioxidative effect Biological and medical sciences Chemoprevention Disease Models, Animal Lipid metabolism Liver Neoplasms - prevention & control Liver tumor Medical sciences Mice Mice, Transgenic Neoplasm Transplantation Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Pharmacology. Drug treatments Tretinoin - analogs & derivatives Tretinoin - pharmacology Tretinoin - therapeutic use Xenograft Model Antitumor Assays |
| title | An antioxidant effect by acyclic retinoid suppresses liver tumor in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A16%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20antioxidant%20effect%20by%20acyclic%20retinoid%20suppresses%20liver%20tumor%20in%20mice&rft.jtitle=Biochemical%20pharmacology&rft.au=Sakabe,%20Tomohiko&rft.date=2007-05-01&rft.volume=73&rft.issue=9&rft.spage=1405&rft.epage=1411&rft.pages=1405-1411&rft.issn=0006-2952&rft.eissn=1873-2968&rft.coden=BCPCA6&rft_id=info:doi/10.1016/j.bcp.2006.12.030&rft_dat=%3Cproquest_cross%3E70316137%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70316137&rft_id=info:pmid/17261273&rft_els_id=S0006295207000020&rfr_iscdi=true |