An antioxidant effect by acyclic retinoid suppresses liver tumor in mice
The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor wer...
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Veröffentlicht in: | Biochemical pharmacology 2007-05, Vol.73 (9), p.1405-1411 |
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Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The mechanisms of prevention of the development of liver cancer by NIK-333, an acyclic retinoid (ACR), were investigated. The transgenic mice expressing the dominant negative form of retinoic acid receptor α (RARE mice), that produce reactive oxygen species and lead to development of liver tumor were used. The effect of NIK-333 on hepatocarcinogenesis in RARE mice was studied. The RARE mice were examined after feeding 0.03% and 0.06% NIK-333 diets at 12 months of age. In the mice fed 0.06% NIK-333 diet, tumor incidence was greatly suppressed, compared to that of wild type mice (0/9 versus 5/9, P |
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ISSN: | 0006-2952 1873-2968 |
DOI: | 10.1016/j.bcp.2006.12.030 |