Association of Functional Heme Oxygenase‐1 Gene Promoter Polymorphism with Renal Transplantation Outcomes

Heme oxygenase‐1 (HO‐1) is a cytoprotective molecule and increased expression in experimental transplant models correlates with reduced graft injury. A functional dinucleotide repeat (GT)n polymorphism, within the HO‐1 promoter, regulates gene expression; a short number of repeats (S‐allele

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of transplantation 2007-04, Vol.7 (4), p.908-913
Hauptverfasser:	Courtney, A. E., McNamee, P. T., Middleton, D., Heggarty, S., Patterson, C. C., Maxwell, A. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cadaver Dinucleotide Repeats - genetics DNA - genetics DNA - isolation & purification Female Genotype Graft Survival - physiology Heme oxygenase Heme Oxygenase-1 - genetics Humans kidney transplantation Kidney Transplantation - mortality Kidney Transplantation - physiology Male Medical sciences Polymerase Chain Reaction Polymorphism, Genetic Prevention and actions Promoter Regions, Genetic protective genes Public health. Hygiene Public health. Hygiene-occupational medicine Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Survival Analysis Tissue Donors transplant outcomes Treatment Outcome
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Beschreibung
Zusammenfassung:	Heme oxygenase‐1 (HO‐1) is a cytoprotective molecule and increased expression in experimental transplant models correlates with reduced graft injury. A functional dinucleotide repeat (GT)n polymorphism, within the HO‐1 promoter, regulates gene expression; a short number of repeats (S‐allele
ISSN:	1600-6135 1600-6143
DOI:	10.1111/j.1600-6143.2006.01726.x