Beryllium Displacement of H+ from Strong Hydrogen Bonds

Beryllium Displacement of H+ from Strong Hydrogen Bonds

It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H+ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a “tetrahedral proton” is thermodynamically preferred, provides...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (15), p.2669-2671
Hauptverfasser: McCleskey, T. Mark, Ehler, Deborah S., Keizer, Timothy S., Asthagiri, Dilip N., Pratt, Lawrence R., Michalczyk, Ryszard, Scott, Brian L.
Format: Artikel
Sprache:eng
Schlagworte:
beryllium
Beryllium - chemistry
bioinorganic chemistry
Hydrogen Bonding
hydrogen bonds
metalloproteins
Metalloproteins - chemistry
Protein Conformation
Protons
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Beschreibung
Zusammenfassung:It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H+ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a “tetrahedral proton” is thermodynamically preferred, provides insight into the transport mechanism of beryllium in chronic beryllium disease.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604623