Semisynthetic Approaches to Laspartomycin Analogues

Laspartomycin C (1), a lipopeptide antibiotic related to amphomycin, consists of a cyclic peptide core and an aspartic acid unit external to the core and linking this to a C15-2,3-unsaturated fatty acid. This was reported initially to be active against Staphylococcus aureus, and more recent studies...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2007-03, Vol.70 (3), p.447-450
Hauptverfasser: Curran, William V, Leese, Richard A, Jarolmen, Howard, Borders, Donald B, Dugourd, Dominique, Chen, Yuchen, Cameron, Dale R
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Sprache:eng
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Zusammenfassung:Laspartomycin C (1), a lipopeptide antibiotic related to amphomycin, consists of a cyclic peptide core and an aspartic acid unit external to the core and linking this to a C15-2,3-unsaturated fatty acid. This was reported initially to be active against Staphylococcus aureus, and more recent studies have shown that it is active against VRE, VISA, and MRSA isolates. The enzymatic cleavage of the fatty acid tail was accomplished with a deacylase produced by Actinoplanes utahensis and resulted in two peptides, designated Peptide 1 and Peptide 2. Semisynthetic derivatives of both peptides have been made, and the principal requirement for biological activity appears to be the presence of an acylaspartic acid.
ISSN:0163-3864
1520-6025
DOI:10.1021/np068062b