Aggregator compounds confound amyloid fibrillization assay

The highly sensitive and artificial biochemical assays that enable high-throughput screening are vulnerable to artifact-generating compounds that occur in drug screening collections. An investigation of known aggregator compounds and amyloid fibrillization inhibitors suggests that such inhibitors op...

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Veröffentlicht in:	Nature chemical biology 2008-03, Vol.4 (3), p.159-160
1. Verfasser:	Rishton, Gilbert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - chemistry Acetophenones - pharmacology Adenosine triphosphatase Amyloid - analysis Amyloid - chemical synthesis Amyloid - chemistry Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - chemistry Benzopyrans - chemistry Benzopyrans - pharmacology Binding sites Biochemical Engineering Biochemistry Bioorganic Chemistry Catalysis Cell Biology Chemical bonds Chemistry Chemistry and Materials Science Chemistry/Food Science Congo Red - chemistry Congo Red - pharmacology Drug Evaluation, Preclinical Flavanones - chemistry Flavanones - pharmacology Microscopy, Electron, Transmission - methods Molecular Structure Molecular Weight news-and-views Particle Size Phenolphthaleins - chemistry Phenolphthaleins - pharmacology Phthalimides - chemistry Phthalimides - pharmacology Sensitivity and Specificity Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The highly sensitive and artificial biochemical assays that enable high-throughput screening are vulnerable to artifact-generating compounds that occur in drug screening collections. An investigation of known aggregator compounds and amyloid fibrillization inhibitors suggests that such inhibitors operate via a nonspecific mechanism in a well-used assay of amyloid fibrillization.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio0308-159