Differential Effects of Interleukin-2 and Interleukin-15 versus Interleukin-21 on CD4+ Cutaneous T-Cell Lymphoma Cells

In this study, we compared the effects of interleukin-2 (IL-2), IL-15, and IL-21 on gene expression, activation of cell signaling pathways, and functional properties of cells derived from CD4+ cutaneous T-cell lymphoma (CTCL). Whereas both IL-2 and IL-15 modulated, in a CTCL cell line, the expressio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-02, Vol.68 (4), p.1083-1091
Hauptverfasser:	MARZEC, Michal, HALASA, Krzysztof, WASIK, Mariusz A, KASPRZYCKA, Monika, WYSOCKA, Maria, XIAOBIN LIU, TOBIAS, John W, BALDWIN, Donald, QIAN ZHANG, ODUM, Niels, ROOK, Alain H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Cell Line, Tumor Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Profiling Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Interleukins - immunology Interleukins - pharmacology Janus Kinase 1 - metabolism Janus Kinase 3 - metabolism Lymphoma, T-Cell, Cutaneous - drug therapy Lymphoma, T-Cell, Cutaneous - enzymology Lymphoma, T-Cell, Cutaneous - genetics Lymphoma, T-Cell, Cutaneous - immunology MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System Medical sciences Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Recombinant Proteins - pharmacology Tumors
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Zusammenfassung:	In this study, we compared the effects of interleukin-2 (IL-2), IL-15, and IL-21 on gene expression, activation of cell signaling pathways, and functional properties of cells derived from CD4+ cutaneous T-cell lymphoma (CTCL). Whereas both IL-2 and IL-15 modulated, in a CTCL cell line, the expression of >1,000 gene transcripts by at least 2-fold, IL-21 up-regulated
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.CAN-07-2403