Effectiveness of Intensive Insulin Therapy by Multiple Daily Injections and Continuous Subcutaneous Infusion: A Comparison Study in Type 2 Diabetes with Conventional Insulin Regimen Failure

Abstract OBJECTIVE: To compare the effectiveness of two intensified insulin regimens, i.e., pump delivery versus multiple daily injections in patients with type 2 diabetes not optimally controlled with conventional insulin therapy. RESEARCH DESIGN AND METHODS: Seventeen type 2 diabetes patients unco...

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Veröffentlicht in:	Hormone and metabolic research 2007-03, Vol.39 (3), p.224-229
Hauptverfasser:	Berthe, E., Lireux, B., Coffin, C., Goulet-Salmon, B., Houlbert, D., Boutreux, S., Fradin, S., Reznik, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Area Under Curve Blood Glucose - analysis Diabetes Mellitus, Type 2 - drug therapy Drug Administration Schedule Female Glycated Hemoglobin A Hemoglobins - metabolism Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Injections, Subcutaneous Insulin - administration & dosage Insulin - analogs & derivatives Insulin - pharmacology Insulin - therapeutic use Insulin Infusion Systems Insulin Lispro Male Middle Aged Monitoring, Physiologic Original Clinical Patient Satisfaction Surveys and Questionnaires Treatment Failure
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Zusammenfassung:	Abstract OBJECTIVE: To compare the effectiveness of two intensified insulin regimens, i.e., pump delivery versus multiple daily injections in patients with type 2 diabetes not optimally controlled with conventional insulin therapy. RESEARCH DESIGN AND METHODS: Seventeen type 2 diabetes patients uncontrolled by two daily injections of regular plus NPH were randomly assigned in a cross-over fashion to either three daily injections of lispro plus NPH or pump device delivering lispro. HbA1c, 6 points capillary blood glucose, 24-hour continuous glucose monitoring system tracings and global satisfaction score were evaluated at the end of each 12-week treatment period. RESULTS: HbA1c decreased from 9.0±1.6% to 8.6±1.6% with multiple injections and 7.7±0.8% with pump device (p
ISSN:	0018-5043 1439-4286
DOI:	10.1055/s-2007-970423