Reactivity Study of 1H-Thieno[3,2-d][1,3]oxazine-2,4-dione toward the Synthesis of Bicyclic 3,4-Dihydro-1H-thieno[3,2-e][1,4]diazepine-2,5-dione Analogues

A series of 10 optically pure 3,4-dihydro-1H-thieno[3,2-e][1,4]diazepine-2,5-dione derivatives has been synthesized in 41−75% yields on treatment of 1H-thieno[3,2-d][1,3]oxazine-2,4-dione with different natural α-amino acids.

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Veröffentlicht in:Journal of organic chemistry 2007-03, Vol.72 (7), p.2662-2665
Hauptverfasser: Brouillette, Yann, Lisowski, Vincent, Fulcrand, Pierre, Martinez, Jean
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container_title Journal of organic chemistry
container_volume 72
creator Brouillette, Yann
Lisowski, Vincent
Fulcrand, Pierre
Martinez, Jean
description A series of 10 optically pure 3,4-dihydro-1H-thieno[3,2-e][1,4]diazepine-2,5-dione derivatives has been synthesized in 41−75% yields on treatment of 1H-thieno[3,2-d][1,3]oxazine-2,4-dione with different natural α-amino acids.
doi_str_mv 10.1021/jo0622882
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source MEDLINE; American Chemical Society Journals
subjects Amides - chemistry
Anhydrides - chemistry
Azepines - chemical synthesis
Azepines - chemistry
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Molecular Structure
Organic chemistry
Oxazines - chemical synthesis
Oxazines - chemistry
Preparations and properties
title Reactivity Study of 1H-Thieno[3,2-d][1,3]oxazine-2,4-dione toward the Synthesis of Bicyclic 3,4-Dihydro-1H-thieno[3,2-e][1,4]diazepine-2,5-dione Analogues
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