Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines

Dichlorofluorophenyl containing aminotriazolothiadiazines ( 6) were synthesized by initial condensation of 2-chloro- N-(substituted phenyl) acetamides ( 4) with triazole ( 3) and further cyclization using POCl 3. The structures of newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Compounds 5a, 5e, 5n, 5o, 6a, 6n, and 6o showed very good antibacterial and antifungal activities at 6.25 μg/ml concentrations. [Display omitted]