The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model
Abstract An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6Al4V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition o...
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| Veröffentlicht in: | Biomaterials 2008-04, Vol.29 (11), p.1730-1736 |
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| creator | Bigi, Adriana Fini, Milena Bracci, Barbara Boanini, Elisa Torricelli, Paola Giavaresi, Gianluca Aldini, Nicolò N Facchini, Alessandro Sbaiz, Fausto Giardino, Roberto |
| description | Abstract An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6Al4V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit cortical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr + HA: 37%; Ti6Al4V + HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb11Zr in comparison with that of HA-coated Ti6Al4V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti–Nb–Zr alloy with the HA coating on bone remodeling and maturation. |
| doi_str_mv | 10.1016/j.biomaterials.2007.12.011 |
| format | Article |
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A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit cortical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr + HA: 37%; Ti6Al4V + HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb11Zr in comparison with that of HA-coated Ti6Al4V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti–Nb–Zr alloy with the HA coating on bone remodeling and maturation.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2007.12.011</identifier><identifier>PMID: 18192001</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Alloys - chemistry ; Alloys - pharmacology ; Animals ; Biomimetic material ; Bone and Bones - drug effects ; Dentistry ; Durapatite - chemistry ; Durapatite - pharmacology ; Hydroxyapatite ; Microscopy, Electron, Scanning ; Models, Animal ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Niobium ; Osteointegration ; Rabbits ; Titanium alloys ; X-Ray Diffraction</subject><ispartof>Biomaterials, 2008-04, Vol.29 (11), p.1730-1736</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-c4594f00348f389ea20c7567e86feb6f48903c4c9381b593fd7f02ed35aecf433</citedby><cites>FETCH-LOGICAL-c561t-c4594f00348f389ea20c7567e86feb6f48903c4c9381b593fd7f02ed35aecf433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2007.12.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18192001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bigi, Adriana</creatorcontrib><creatorcontrib>Fini, Milena</creatorcontrib><creatorcontrib>Bracci, Barbara</creatorcontrib><creatorcontrib>Boanini, Elisa</creatorcontrib><creatorcontrib>Torricelli, Paola</creatorcontrib><creatorcontrib>Giavaresi, Gianluca</creatorcontrib><creatorcontrib>Aldini, Nicolò N</creatorcontrib><creatorcontrib>Facchini, Alessandro</creatorcontrib><creatorcontrib>Sbaiz, Fausto</creatorcontrib><creatorcontrib>Giardino, Roberto</creatorcontrib><title>The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6Al4V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit cortical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr + HA: 37%; Ti6Al4V + HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb11Zr in comparison with that of HA-coated Ti6Al4V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti–Nb–Zr alloy with the HA coating on bone remodeling and maturation.</description><subject>Advanced Basic Science</subject><subject>Alloys - chemistry</subject><subject>Alloys - pharmacology</subject><subject>Animals</subject><subject>Biomimetic material</subject><subject>Bone and Bones - drug effects</subject><subject>Dentistry</subject><subject>Durapatite - chemistry</subject><subject>Durapatite - pharmacology</subject><subject>Hydroxyapatite</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Animal</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Niobium</subject><subject>Osteointegration</subject><subject>Rabbits</subject><subject>Titanium alloys</subject><subject>X-Ray Diffraction</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGLFDEQhYMo7uzqX5DgwVu3qSTdnXgQZHVVWPTgePES0ukKm7GnMyY9Yv9708yA4mWFQEj4XlXxXhHyHFgNDNqXu7oPcW9nTMGOueaMdTXwmgE8IBtQnaoazZqHZMNA8kq3wC_IZc47Vt5M8sfkAhToIoMNsds7pAnzIU4ZafS0jxPSOdLJTtGlJc92HEP5uluGFH8t9mDnMGPlYuk_0G0A8akH-JZo4eJCw0TtesLejnQfBxyfkEe-jIlPz_cV-Xrzbnv9obr9_P7j9ZvbyjUtzJWTjZaeMSGVF0qj5cx1Tduhaj32rZdKM-Gk00JB32jhh84zjoNoLDovhbgiL051Dyn-OGKezT5kh-NoJ4zHbDrGlVZM3gsKDh0D3t4Lcta0SktewFcn0KWYc0JvDqkYkBYDzKyRmZ35OzKzRmaAmxJZET87dzn2exz-SM8ZFeDtCcDi3s-AyWQXcHI4hIRuNkMM_9fn9T9lXAk2ODt-xwXzLh7TtGrA5CIwX9blWXeHFTOKHY34Da9Mwww</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Bigi, Adriana</creator><creator>Fini, Milena</creator><creator>Bracci, Barbara</creator><creator>Boanini, Elisa</creator><creator>Torricelli, Paola</creator><creator>Giavaresi, Gianluca</creator><creator>Aldini, Nicolò N</creator><creator>Facchini, Alessandro</creator><creator>Sbaiz, Fausto</creator><creator>Giardino, Roberto</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model</title><author>Bigi, Adriana ; Fini, Milena ; Bracci, Barbara ; Boanini, Elisa ; Torricelli, Paola ; Giavaresi, Gianluca ; Aldini, Nicolò N ; Facchini, Alessandro ; Sbaiz, Fausto ; Giardino, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-c4594f00348f389ea20c7567e86feb6f48903c4c9381b593fd7f02ed35aecf433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Advanced Basic Science</topic><topic>Alloys - chemistry</topic><topic>Alloys - pharmacology</topic><topic>Animals</topic><topic>Biomimetic material</topic><topic>Bone and Bones - drug effects</topic><topic>Dentistry</topic><topic>Durapatite - chemistry</topic><topic>Durapatite - pharmacology</topic><topic>Hydroxyapatite</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Animal</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Niobium</topic><topic>Osteointegration</topic><topic>Rabbits</topic><topic>Titanium alloys</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bigi, Adriana</creatorcontrib><creatorcontrib>Fini, Milena</creatorcontrib><creatorcontrib>Bracci, Barbara</creatorcontrib><creatorcontrib>Boanini, Elisa</creatorcontrib><creatorcontrib>Torricelli, Paola</creatorcontrib><creatorcontrib>Giavaresi, Gianluca</creatorcontrib><creatorcontrib>Aldini, Nicolò N</creatorcontrib><creatorcontrib>Facchini, Alessandro</creatorcontrib><creatorcontrib>Sbaiz, Fausto</creatorcontrib><creatorcontrib>Giardino, Roberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bigi, Adriana</au><au>Fini, Milena</au><au>Bracci, Barbara</au><au>Boanini, Elisa</au><au>Torricelli, Paola</au><au>Giavaresi, Gianluca</au><au>Aldini, Nicolò N</au><au>Facchini, Alessandro</au><au>Sbaiz, Fausto</au><au>Giardino, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>29</volume><issue>11</issue><spage>1730</spage><epage>1736</epage><pages>1730-1736</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6Al4V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit cortical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr + HA: 37%; Ti6Al4V + HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb11Zr in comparison with that of HA-coated Ti6Al4V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti–Nb–Zr alloy with the HA coating on bone remodeling and maturation.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>18192001</pmid><doi>10.1016/j.biomaterials.2007.12.011</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biomaterials, 2008-04, Vol.29 (11), p.1730-1736 |
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| subjects | Advanced Basic Science Alloys - chemistry Alloys - pharmacology Animals Biomimetic material Bone and Bones - drug effects Dentistry Durapatite - chemistry Durapatite - pharmacology Hydroxyapatite Microscopy, Electron, Scanning Models, Animal Nanoparticles - chemistry Nanoparticles - ultrastructure Niobium Osteointegration Rabbits Titanium alloys X-Ray Diffraction |
| title | The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model |
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