Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.)
Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In...
Gespeichert in:
| Veröffentlicht in: | Phytomedicine (Stuttgart) 2007-04, Vol.14 (4), p.250-255 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 255 |
|---|---|
| container_issue | 4 |
| container_start_page | 250 |
| container_title | Phytomedicine (Stuttgart) |
| container_volume | 14 |
| creator | Breyer, Anja Elstner, Matthias Gillessen, Thomas Weiser, Dieter Elstner, Erich |
| description | Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of
Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported. |
| doi_str_mv | 10.1016/j.phymed.2007.02.001 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_70288452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A163466140</galeid><els_id>S0944711307000293</els_id><sourcerecordid>A163466140</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-c273aa1da775902fb87fd9642bdeb95c9112a86873f45b1855a7f67dae0085843</originalsourceid><addsrcrecordid>eNp9kV-L1DAUxYso7rj6DUQCgn8eWpNM0rQvwrLojjLggyv4FtLkdidDm4xJqs6D393UDoIwSB5uyP2dG849RfGU4IpgUr_ZV4fdcQRTUYxFhWmFMblXrEhNmhK3_Ov9YoVbxkpByPqieBTjPgOsFfhhcUHEmtUtr1fFr5thSmpUCUrrzKTBIA3DgAyotEPWIQdT8E4NaHNL6Z9eRDYilRK4KcsM6o4IfqagdIqoD35En1OFPvqdexnRDx8SeoU2xwMEq6cR5dr7oFK-bqvXj4sHvRoiPDnVy-LL-3e315ty--nmw_XVttSs5qnUVKyVIkYJwVtM-64RvWlrRjsDXct1SwhVTd2Idc94RxrOlehrYRRg3PCGrS-LF8vcQ_DfJohJjjbOXpQDP0UpMG0axmkGny_gnRpAWtf72dgMyytS56XVhOFMlWeoO3AQ1OAd9DY__8NXZ_h8DIxWnxWwRaCDjzFALw_BjiocJcFyTl_u5ZK-nNOXmMocbpY9O9mcurn3V3SKOwNvFwDysr9bCDJqCy6nbgPoJI23___hN_L6wCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70288452</pqid></control><display><type>article</type><title>Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.)</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Breyer, Anja ; Elstner, Matthias ; Gillessen, Thomas ; Weiser, Dieter ; Elstner, Erich</creator><creatorcontrib>Breyer, Anja ; Elstner, Matthias ; Gillessen, Thomas ; Weiser, Dieter ; Elstner, Erich</creatorcontrib><description>Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of
Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2007.02.001</identifier><identifier>PMID: 17346956</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Antioxidants ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Apoptosis - drug effects ; Causes of ; Cell death ; Cells, Cultured - drug effects ; Cytoprotective effects ; Dose-Response Relationship, Drug ; Glutamate ; Glutamate-induced cell death in neuronal HT22 cells ; Glutamic Acid - pharmacology ; Health aspects ; Hippocampus - cytology ; Hippocampus - drug effects ; Humans ; Hypericum ; Hypericum flavonoids ; Neuroprotective Agents - administration & dosage ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Reactive oxygen</subject><ispartof>Phytomedicine (Stuttgart), 2007-04, Vol.14 (4), p.250-255</ispartof><rights>2007 Elsevier GmbH</rights><rights>COPYRIGHT 2007 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c273aa1da775902fb87fd9642bdeb95c9112a86873f45b1855a7f67dae0085843</citedby><cites>FETCH-LOGICAL-c465t-c273aa1da775902fb87fd9642bdeb95c9112a86873f45b1855a7f67dae0085843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2007.02.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17346956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Breyer, Anja</creatorcontrib><creatorcontrib>Elstner, Matthias</creatorcontrib><creatorcontrib>Gillessen, Thomas</creatorcontrib><creatorcontrib>Weiser, Dieter</creatorcontrib><creatorcontrib>Elstner, Erich</creatorcontrib><title>Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.)</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of
Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.</description><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Apoptosis - drug effects</subject><subject>Causes of</subject><subject>Cell death</subject><subject>Cells, Cultured - drug effects</subject><subject>Cytoprotective effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Glutamate</subject><subject>Glutamate-induced cell death in neuronal HT22 cells</subject><subject>Glutamic Acid - pharmacology</subject><subject>Health aspects</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Humans</subject><subject>Hypericum</subject><subject>Hypericum flavonoids</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Reactive oxygen</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1DAUxYso7rj6DUQCgn8eWpNM0rQvwrLojjLggyv4FtLkdidDm4xJqs6D393UDoIwSB5uyP2dG849RfGU4IpgUr_ZV4fdcQRTUYxFhWmFMblXrEhNmhK3_Ov9YoVbxkpByPqieBTjPgOsFfhhcUHEmtUtr1fFr5thSmpUCUrrzKTBIA3DgAyotEPWIQdT8E4NaHNL6Z9eRDYilRK4KcsM6o4IfqagdIqoD35En1OFPvqdexnRDx8SeoU2xwMEq6cR5dr7oFK-bqvXj4sHvRoiPDnVy-LL-3e315ty--nmw_XVttSs5qnUVKyVIkYJwVtM-64RvWlrRjsDXct1SwhVTd2Idc94RxrOlehrYRRg3PCGrS-LF8vcQ_DfJohJjjbOXpQDP0UpMG0axmkGny_gnRpAWtf72dgMyytS56XVhOFMlWeoO3AQ1OAd9DY__8NXZ_h8DIxWnxWwRaCDjzFALw_BjiocJcFyTl_u5ZK-nNOXmMocbpY9O9mcurn3V3SKOwNvFwDysr9bCDJqCy6nbgPoJI23___hN_L6wCw</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Breyer, Anja</creator><creator>Elstner, Matthias</creator><creator>Gillessen, Thomas</creator><creator>Weiser, Dieter</creator><creator>Elstner, Erich</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.)</title><author>Breyer, Anja ; Elstner, Matthias ; Gillessen, Thomas ; Weiser, Dieter ; Elstner, Erich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-c273aa1da775902fb87fd9642bdeb95c9112a86873f45b1855a7f67dae0085843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Apoptosis - drug effects</topic><topic>Causes of</topic><topic>Cell death</topic><topic>Cells, Cultured - drug effects</topic><topic>Cytoprotective effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Glutamate</topic><topic>Glutamate-induced cell death in neuronal HT22 cells</topic><topic>Glutamic Acid - pharmacology</topic><topic>Health aspects</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Humans</topic><topic>Hypericum</topic><topic>Hypericum flavonoids</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Reactive oxygen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Breyer, Anja</creatorcontrib><creatorcontrib>Elstner, Matthias</creatorcontrib><creatorcontrib>Gillessen, Thomas</creatorcontrib><creatorcontrib>Weiser, Dieter</creatorcontrib><creatorcontrib>Elstner, Erich</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Breyer, Anja</au><au>Elstner, Matthias</au><au>Gillessen, Thomas</au><au>Weiser, Dieter</au><au>Elstner, Erich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.)</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>14</volume><issue>4</issue><spage>250</spage><epage>255</epage><pages>250-255</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of
Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>17346956</pmid><doi>10.1016/j.phymed.2007.02.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2007-04, Vol.14 (4), p.250-255 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70288452 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis - drug effects Causes of Cell death Cells, Cultured - drug effects Cytoprotective effects Dose-Response Relationship, Drug Glutamate Glutamate-induced cell death in neuronal HT22 cells Glutamic Acid - pharmacology Health aspects Hippocampus - cytology Hippocampus - drug effects Humans Hypericum Hypericum flavonoids Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Reactive oxygen |
| title | Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T12%3A26%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutamate-induced%20cell%20death%20in%20neuronal%20HT22%20cells%20is%20attenuated%20by%20extracts%20from%20St.%20John's%20wort%20(%20Hypericum%20perforatum%20L.)&rft.jtitle=Phytomedicine%20(Stuttgart)&rft.au=Breyer,%20Anja&rft.date=2007-04-01&rft.volume=14&rft.issue=4&rft.spage=250&rft.epage=255&rft.pages=250-255&rft.issn=0944-7113&rft.eissn=1618-095X&rft_id=info:doi/10.1016/j.phymed.2007.02.001&rft_dat=%3Cgale_proqu%3EA163466140%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70288452&rft_id=info:pmid/17346956&rft_galeid=A163466140&rft_els_id=S0944711307000293&rfr_iscdi=true |