Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort ( Hypericum perforatum L.)

Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2007-04, Vol.14 (4), p.250-255
Hauptverfasser:	Breyer, Anja, Elstner, Matthias, Gillessen, Thomas, Weiser, Dieter, Elstner, Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis - drug effects Causes of Cell death Cells, Cultured - drug effects Cytoprotective effects Dose-Response Relationship, Drug Glutamate Glutamate-induced cell death in neuronal HT22 cells Glutamic Acid - pharmacology Health aspects Hippocampus - cytology Hippocampus - drug effects Humans Hypericum Hypericum flavonoids Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Reactive oxygen
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Zusammenfassung:	Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.
ISSN:	0944-7113 1618-095X
DOI:	10.1016/j.phymed.2007.02.001