Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement

Core–multishell nanoparticles: Near‐IR‐resonant rhodamine‐encapsulated poly(lactic‐co‐glycolic acid) (PLGA)–Mn/Au half‐shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic reson...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2008-02, Vol.4 (2), p.192-196
Hauptverfasser:	Park, Huiyul, Yang, Jaemoon, Seo, Sungbaek, Kim, Kyujung, Suh, Jinsuk, Kim, Donghyun, Haam, Seungjoo, Yoo, Kyung-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials contrast enhancement Contrast Media core/shell materials Drug Delivery Systems encapsulation Gold Hot Temperature - therapeutic use Lactic Acid Magnetic Resonance Imaging Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microscopy, Fluorescence Phototherapy Polyglycolic Acid Polymers Rhodamines Spectroscopy, Near-Infrared
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Zusammenfassung:	Core–multishell nanoparticles: Near‐IR‐resonant rhodamine‐encapsulated poly(lactic‐co‐glycolic acid) (PLGA)–Mn/Au half‐shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from the PLGA NPs is about twice as great as that without NIR irradiation, indicating photothermally controlled drug delivery possibilities.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200700807