Evolution of bone mineral density in AIDS patients on treatment with zidovudine/lamivudine plus abacavir or lopinavir/ritonavir

Objectives The aim of the study was to determine the factors that may contribute to decreases in bone mineral density (BMD) in patients with AIDS. Methods This was a prospective, non‐randomized study. Dual X‐ray absorptiometry (DXA) was used to determine the BMD of the lumbar spine, femoral neck and...

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Veröffentlicht in:	HIV medicine 2008-02, Vol.9 (2), p.89-95
Hauptverfasser:	Rivas, P, Górgolas, M, García‐Delgado, R, Díaz‐Curiel, M, Goyenechea, A, Fernández‐Guerrero, ML
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adult adverse effects Anti-HIV Agents - administration & dosage Antiretroviral Therapy, Highly Active Bone Density - drug effects bones Case-Control Studies Dideoxynucleosides - administration & dosage Femur Neck highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - physiopathology Humans Lamivudine - administration & dosage Lopinavir Lumbar Vertebrae Male Middle Aged osteoporosis Prospective Studies Pyrimidinones - administration & dosage Ritonavir - administration & dosage Zidovudine - administration & dosage
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Zusammenfassung:	Objectives The aim of the study was to determine the factors that may contribute to decreases in bone mineral density (BMD) in patients with AIDS. Methods This was a prospective, non‐randomized study. Dual X‐ray absorptiometry (DXA) was used to determine the BMD of the lumbar spine, femoral neck and distal radius in treatment‐naïve HIV‐infected male patients with AIDS before and after 1 year of treatment with zidovudine (ZDV)/lamivudine (3TC) plus abacavir (ABC) or lopinavir/ritonavir (LPV/r). Results Basal DXA was performed in 50 patients with CD4 counts
ISSN:	1464-2662 1468-1293
DOI:	10.1111/j.1468-1293.2007.00525.x