Palladium/Phosphite-Catalyzed 1,4-Addition of Arylboronic Acids to Acrylic Acid Derivatives

Palladium/Phosphite-Catalyzed 1,4-Addition of Arylboronic Acids to Acrylic Acid Derivatives

1,4-Addition of arylboronic acids to acrylic acid derivatives proceeds efficiently in the presence of a palladium catalyst system of Pd(OAc)2/(PhO)3P to produce the corresponding 3-arylpropionic acid derivatives. The use of the phosphite ligand is the key to conducting the addition smoothly with sup...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2008-02, Vol.73 (4), p.1590-1592
Hauptverfasser: Horiguchi, Hakaru, Tsurugi, Hayato, Satoh, Tetsuya, Miura, Masahiro
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Catalysts: preparations and properties
Chemistry
Exact sciences and technology
General and physical chemistry
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:1,4-Addition of arylboronic acids to acrylic acid derivatives proceeds efficiently in the presence of a palladium catalyst system of Pd(OAc)2/(PhO)3P to produce the corresponding 3-arylpropionic acid derivatives. The use of the phosphite ligand is the key to conducting the addition smoothly with suppressing the competing Mizoroki−Heck-type oxidative coupling.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo702546t