Physical work-induced oxidative stress is exacerbated in young cigarette smokers

Physical work-induced oxidative stress is exacerbated in young cigarette smokers

Both cigarette smoking and strenuous physical work are associated with increased oxidative stress, which is implicated in the pathogenesis of cardiovascular disease. No study to date has measured oxidative stress in response to graded exercise in cigarette smokers. We compared oxidative stress bioma...

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Veröffentlicht in:Nicotine & tobacco research 2007-02, Vol.9 (2), p.205-211
Hauptverfasser: Bloomer, Richard J., Creasy, Andrea K., Smith, Webb A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
Exercise - physiology
Humans
Malondialdehyde - blood
Oxidative Stress - physiology
Protein Carbonylation - physiology
Smoking - blood
Smoking - metabolism
Work
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Zusammenfassung:Both cigarette smoking and strenuous physical work are associated with increased oxidative stress, which is implicated in the pathogenesis of cardiovascular disease. No study to date has measured oxidative stress in response to graded exercise in cigarette smokers. We compared oxidative stress biomarkers before and after strenuous exercise (Bruce treadmill protocol) in 14 cigarette smokers and 15 nonsmokers of similar age (24±6 years) and fitness status. Plasma protein carbonyls (PC), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) were measured pre- and postexercise. Smoking status (p
ISSN:1462-2203
1469-994X
DOI:10.1080/14622200601078541