New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2 : [g]-Fused and hetero-fused systems

The synthesis and the SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported. The new scaffolds of the [g]-fused and the hetero-fused tricyclic benzazepine are here reported together with their pharmacokinetic profile.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2008-02, Vol.18 (3), p.908-912
Hauptverfasser:	MICHELI, Fabrizio, BONANOMI, Giorgio, PETRONE, Marcella, TEDESCO, Giovanna, TERRENI, Silvia, WORBY, Angela, HEIDBREDER, Christian, BRAGGIO, Simone, CAPELLI, Anna Maria, DAMIANI, Federica, DI FABIO, Romano, DONATI, Daniele, GENTILE, Gabriella, HAMPRECHT, Dieter, PERINI, Ornella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzazepines - chemical synthesis Benzazepines - chemistry Benzazepines - pharmacology Biological and medical sciences Catecholaminergic system Combinatorial Chemistry Techniques Dopamine Antagonists - chemical synthesis Dopamine Antagonists - chemistry Dopamine Antagonists - pharmacology Drug Design Medical sciences Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Receptors, Dopamine D3 - antagonists & inhibitors Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The synthesis and the SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported. The new scaffolds of the [g]-fused and the hetero-fused tricyclic benzazepine are here reported together with their pharmacokinetic profile.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.12.042