Design, synthesis and structure–activity study of shorter hexa peptide analogues as HIV-1 protease inhibitors

The design, synthesis and HIV-1 protease inhibition of the shorter synthetic hexa peptides are discussed. Leu-Leu-Glu-Tyr-Val-Xaa. Where, Xaa = Phe, Met, Tyr or Trp. Inhibition of HIV-1 protease enzyme can render the Human Immunodeficiency Virus (HIV-1) non-infectious in vitro. Previous studies have shown that several shorter peptides were discovered as HIV-1 protease inhibitors. In this context, a series of shorter synthetic hexapeptides, Leu-Leu-Glu-Tyr-Val-Xaa (Xaa = Phe, Met, Tyr and Trp), were designed. The synthesized hexa peptides were screened for their HIV-1 protease inhibition. These peptides showed moderately good HIV-1 protease inhibition when compared to acetyl pepstatin.