Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis

Abstract Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with str...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Psychiatry research. Neuroimaging 2008-02, Vol.162 (2), p.167-171
Hauptverfasser:	Roiz-Santiáñez, Roberto, Crespo-Facorro, Benedicto, Pérez-Iglesias, Rocío, Pelayo-Terán, José María, Carrasco-Marín, Eugenio, Mata, Ignacio, Sánchez, Elena, Leyva-Cobián, Francisco, Vázquez-Barquero, José Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alleles Base Pairing Biological and medical sciences Brain - pathology Brain morphometry Gene Gene Frequency - genetics Genetic Carrier Screening Genotype Homozygote Humans Interleukin 1 Receptor Antagonist Protein - genetics Interleukin-1 receptor antagonist genotype Longitudinal Studies Magnetic Resonance Imaging Medical sciences MRI Occipital Lobe - pathology Polymorphism, Genetic - genetics Prospective Studies Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - diagnosis Psychotic Disorders - genetics Psychotic Disorders - pathology Radiology Repetitive Sequences, Nucleic Acid - genetics Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia - pathology Structural neuroimaging
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients. We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness.
ISSN:	0925-4927 1872-7506
DOI:	10.1016/j.pscychresns.2007.10.001