The Effects of Dose, Route, and Repeated Dosing on the Disposition and Kinetics of Tetrabromobisphenol A in Male F-344 Rats

Studies were conducted to characterize the metabolic and dispositional fate of 14C–tetrabromobisphenol A (TBBPA)—a commonly used brominated flame retardant, in male Fischer-344 rats. The percent of dose eliminated as total radioactivity in feces at 72 h following three different single oral doses (2, 20, or 200 mg/kg) of 14C-TBBPA was 90% or greater for all doses. Most of the dose was eliminated in the first 24 h. At 72 h after administration of the highest dose, the amounts of 14C found in the tissues were minimal (0.2–0.9%). With repeated daily oral doses (20 mg/kg) for 5 or 10 days, the cumulative percent dose eliminated in the feces was 85.1 ± 2.8 and 97.9 ± 1.1, respectively. In all studies radioactivity recovered in urine was minimal,