Significance of tissue anisotropy in optical tomography of the infant brain

We study the effect of tissue anisotropy in optical tomography of neonates. A Monte Carlo method capable of modeling photon migration in an arbitrary 3D tissue model with spatially varying optical properties and tissue anisotropy is used for simulating measurements of neonates. Anatomical and diffus...

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Veröffentlicht in:	Applied Optics 2007-04, Vol.46 (10), p.1633-1640
Hauptverfasser:	Heiskala, Juha, Neuvonen, Tuomas, Grant, P Ellen, Nissilä, Ilkka
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anisotropy Brain - anatomy & histology Computer Simulation Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional - methods Infant Infant, Newborn Models, Neurological Models, Statistical Monte Carlo Method Reproducibility of Results Sensitivity and Specificity Tomography, Optical - methods
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Zusammenfassung:	We study the effect of tissue anisotropy in optical tomography of neonates. A Monte Carlo method capable of modeling photon migration in an arbitrary 3D tissue model with spatially varying optical properties and tissue anisotropy is used for simulating measurements of neonates. Anatomical and diffusion tensor magnetic resonance imaging of neonates are used for creating the anatomical models. We find that tissue anisotropy affects the measured signal and the pattern of sensitivity in optical measurements.
ISSN:	1559-128X 0003-6935 1539-4522
DOI:	10.1364/AO.46.001633