Coronary artery occlusion alters expression of substance P and its mRNA in spinal dorsal horn in rats

Abstract The painful sensation during acute myocardial ischemia or infarction is a common symptom and results from neural activity in humans. Little is known about the role of neuropeptides in this effect of myocardial ischemia. The aim of the current study was to investigate the role of substance P...

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Veröffentlicht in:	Neuroscience 2007-03, Vol.145 (2), p.669-675
Hauptverfasser:	Guo, Z, Niu, Y.-L, Zhang, J.-W, Yao, T.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - metabolism Angina Pectoris - genetics Angina Pectoris - metabolism Angina Pectoris - physiopathology Animals Biological and medical sciences coronary artery occlusion Coronary Stenosis - genetics Coronary Stenosis - metabolism Coronary Stenosis - physiopathology dorsal root ganglion Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Gene Expression Regulation - physiology Heart - innervation Male myocardial ischemia Myocardial Ischemia - genetics Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Neurology Neurons, Afferent - metabolism Nociceptors - metabolism Posterior Horn Cells - metabolism preprotachykinin Protein Precursors - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism spinal dorsal horn substance P Substance P - genetics Substance P - metabolism Tachykinins - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	Abstract The painful sensation during acute myocardial ischemia or infarction is a common symptom and results from neural activity in humans. Little is known about the role of neuropeptides in this effect of myocardial ischemia. The aim of the current study was to investigate the role of substance P in mediating the noxious neural signals in spinal cord in acute myocardial ischemia by exploring the change in substance P and its mRNA in thoracic dorsal root ganglia and spinal dorsal horn (T1–T5) after coronary artery occlusion. The experiment was performed with immunohistochemistry, enzyme immunoassay and real time reverse transcription–polymerase chain reaction techniques on rats’ hearts. In acute myocardial ischemia (
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2006.12.008